Conformationally stabilized HIV envelope immunogens

US8715686B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Peter Kwong · Washington, US
• John Mascola · Rockville, US
• Gary J. Nabel · Cambridge, US
• Richard Wyatt · Village of La Jolla, US
• Barna Dey · Germantown, US
• Ling Xu · Potomac, US
• Tongqing Zhou · Boyds, US
• Joseph Sodroski · Medford, US
• Wen Yuan · Watertown, US
• Shi-Hua Xiang · Boston, US

Key dates

• Filing date: Aug 14, 2012
• Grant date: May 6, 2014
• Expiry date: Aug 21, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.