Patent · US Active

DNA polymerases with increased 3'-mismatch discrimination

US8715991B2 · kind B2 · utility

1Cited by

0References

11Claims

0Family size

Assignee

Roche Molecular Systems, Inc. · US

Inventors

Fred Reichert · Oakland, US
Keith Bauer · Los Altos, US
Thomas W. Myers · Dublin, US

Key dates

Filing date	Jun 17, 2011
Grant date	May 6, 2014
Priority date	—
Expiry date	Jan 5, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y207/07007
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.