Class- and isoform-specific HDAC inhibitors and uses thereof
US8716344B2 · kind B2 · utility
7Cited by
79References
21Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Aug 11, 2010 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | Aug 11, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of the following formulawherein R3 is a fluorescent tag. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of the above formula in the presence of a test compound; and determining the activity of the HDAC protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.