Sub-region of a plasmodium protein with improved vaccine potential, and medical uses thereof
US8716443B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 7, 2009 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | Sep 19, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application relates to a sub-region of a Plasmodium protein, with improved vaccine potential, and to medical uses thereof, notably for treatment or diagnosis of malaria. The present invention notably provides unstructured or unfolded polypeptides deriving from the PFF0165c protein of P. falciparum 3D7. The polypeptides of the invention have a high antigenicity, a high immunogenicity, have a high parasite-killing activity in the ADCI assay, and are strongly associated with clinical protection against malaria, and. The present invention thereby provides a vaccine for the palliative and/or curative treatment of malaria, which is specifically intended for infants, toddlers, children under the age of 5, pregnant women.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.