Artificial immune system: methods of use

US8722402B2 · kind B2 · utility

Assignees

• SANOFI PASTEUR VAXDESIGN CORPORATION · US
• Mount Sinai School of Medicine · US
• Whitehead Institute · US
• Massachusetts Institute of Technology · US
• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• William L. Warren · Orlando, US
• Heather Fahlenkamp · Cleveland, US
• Russell Higbee · Orlando, US
• Anatoly Kachurin · Orlando, US
• Conan Li · Los Altos, US
• Mike Nguyen · Orlando, US
• Robert Parkhill · Orlando, US
• Guzman Sanchez-Schmitz · Orlando, US
• Darrell J. Irvine · Arlington, US
• Gwendalyn J. Randolph · New York, US
• Nir Harcohen · Brookline, US
• Bruce Torbett · Encinitas, US

Key dates

• Filing date: Sep 10, 2012
• Grant date: May 13, 2014
• Expiry date: Sep 10, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.