Gene expression signature of genomic instability in breast cancer

US8741574B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• West Virginia University Research Corporation · US

Inventors

• Karl Thomas Ried · Bethesda, US
• Jens Habermann · Celle, DE
• Nancy Lan Guo · Morgantown, US
• Gert Auer · Solna, SE

Key dates

• Filing date: Sep 15, 2009
• Grant date: Jun 3, 2014
• Expiry date: Feb 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods of assessing genomic instability in breast cancer tissue by measuring the expression level of genes CDKN2A, SCYA18, STK15, NXF1, cDNA Dkfzp762M127, p28 KIAA0882, MYB, Human clone 23948, RERG, HNF3A, and ACADSB or a nucleic acid sequence comprising about 90% or greater sequence identity to SEQ ID NO: 21 in breast cancer tissue, an array suitable for use in such methods, and related methods and compositions.