Dipeptoid prodrugs and the use thereof

US8741834B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Hans-Georg Lerchen · Leverkusen, DE
• Daniel Meibom · Leverkusen, DE
• Alexandros Vakalopoulos · Hilden, DE
• Barbara Albrecht-Küpper · Uerdingen, DE
• Joerg Keldenich · Wuppertal, DE
• Katja Zimmermann · Mülheim an der Ruhr, DE
• Peter Nell · Wuppertal, DE
• Ursula Krenz · Leichlingen, DE

Key dates

• Filing date: Dec 3, 2009
• Grant date: Jun 3, 2014
• Expiry date: Dec 17, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06165
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to dipeptide-like prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.