Soluble guanylate cyclase activators

US8741910B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Linda Brockunier · Orange, US
• Jian Guo · Lawrence, US
• Emma R. Parmee · Scotch Plains, US
• Subharekha Raghavan · Teaneck, US
• Keith Rosauer · New Hampton, US
• Darby Schmidt · Arlington, US
• John E. Stelmach · Westfield, US

Key dates

• Filing date: Nov 16, 2009
• Grant date: Jun 3, 2014
• Expiry date: Sep 20, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I.