Amino-pyrrolidine-azetidine diamides as monoacylglycerol lipase inhibitors

US8748417B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Yue-Mei Zhang · Wellesley, US
• Peter J. Connolly · New Providence, US
• Shu-Chen Lin · Doylestown, US
• Mark J. Macielag · Spring House, US

Key dates

• Filing date: Mar 13, 2013
• Grant date: Jun 10, 2014
• Expiry date: Mar 13, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows:wherein Y, Z, and R1, and R2 are defined herein.