Patent · US Active

Optimized Fc variants

US8753628B2 · kind B2 · utility

4Cited by

47References

14Claims

0Family size

Assignee

Xencor, Inc. · US

Inventors

Gregory Alan Lazar · Los Angeles, US
Wei Dang · Pasadena, US
John Desjarlais · Pasadena, US
Sher Bahadur Karki · Pasadena, US
Omid Vafa · Monrovia, US
Robert Hayes · Paoli, US
Jost Vielmetter · Altadena, US

Key dates

Filing date	Jun 11, 2013
Grant date	Jun 17, 2014
Priority date	—
Expiry date	Jun 11, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.