Pyrazole compounds as CRTH2 antagonists

US8759386B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Ralf Anderskewitz · Laupheim, DE
• Domnic Martyres · Biberach, DE
• Thorsten Oost · Biberach an der Riß, DE
• Wolfgang Rist · Ingelheim am Rhein, DE
• Peter Seither · Biberach an der Riß, DE

Key dates

• Filing date: Jan 19, 2012
• Grant date: Jun 24, 2014
• Expiry date: Nov 7, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrazole compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof,wherein Ra, Rb, Rc, Rd, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, n and R3 have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical formulations containing the compounds and to pharmaceutical formulations containing the compounds in combination with one or more active substances.