Cyclobutyl sulfones as notch sparing gamma secretase inhibitors
US8759579B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Apr 17, 2009 |
| Grant date | Jun 24, 2014 |
| Priority date | — |
| Expiry date | May 13, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.