Positive allosteric modulators of MGLUR2
US8765784B2 · kind B2 · utility
18Cited by
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19Claims
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Assignee
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Key dates
| Filing date | Jun 6, 2011 |
| Grant date | Jul 1, 2014 |
| Priority date | — |
| Expiry date | Jun 6, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.