Patent · US Active

Genome editing of a Rosa locus using zinc-finger nucleases

US8771985B2 · kind B2 · utility

34Cited by

26References

20Claims

0Family size

Assignees

Sangamo Biosciences, Inc. · US
Sigma-Aldvich Co. LLC · US

Inventors

Xiaoxia Cui · Chesterfield, US
Gregory D. Davis · Berkeley, US
Philip D. Gregory · Richmond, US
Michael C. Holmes · Richmond, US
Edward Weinstein · Chesterfield, US

Key dates

Filing date	Apr 25, 2011
Grant date	Jul 8, 2014
Priority date	—
Expiry date	Mar 12, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/81
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.