Methods and compositions related to targeting monoacylglycerol lipase
US8772318B2 · kind B2 · utility
6Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 10, 2009 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Aug 20, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/531
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compounds that selectively inhibit monoacylglycerol lipase (MAGL). The invention also provides methods of using the MAGL selective inhibitors to stimulate 2-Arachidonoylglycerol (2-AG) mediated endocannabinoid signaling in vivo, and to treat conditions that are associated with or linked to endocannabinoid signaling. The invention additionally provides methods of treating cancer or inhibiting tumor growth by targeting MAGL with MAGL specific inhibitors. The invention further provides methods of screening for MAGL inhibitors with improved biochemical and pharmaceutical properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.