Compositions and methods for modulating RSV infection and immunity

US8778354B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Ralph A. Tripp · Watkinsville, US
• Les Jones · Peachtree City, US
• Larry J. Anderson · Blue Springs, US

Key dates

• Filing date: Jan 25, 2012
• Grant date: Jul 15, 2014
• Expiry date: Jan 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18522
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods are provided for the treatment or prevention of RSV disease by modulating RSV infection and immunity. In particular, amino acid sequences in the RSV G glycoprotein, containing the chemokine motif defined as C-X-X-X-C (or CX3C), are identified that are essential in causing RSV infection and disease. The chemokine motif is biologically active and participates in virus binding to and infection of susceptible cells. The prevention or treatment of RSV infection is achieved by interfering with the motif, such as by administering a vaccine in which the motif is altered or by administration or induction of blocking molecules that inhibit the biological activity of the motif.