Antibodies against human IL33R and uses thereof

US8785153B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Georg Fertig · Penzberg, DE
• Jens Fischer · Penzberg, DE
• Guy Georges · Habach, DE
• Klaus Kaluza · Bad Heilbrunn, DE
• Valeria Lifke · Penzberg, DE
• Joerg Moelleken · Penzberg, DE
• Sonja Offner · Penzberg, DE
• Achal Pashine · Mahwah, US
• Stefan Seeber · Penzberg, DE

Key dates

• Filing date: Feb 22, 2012
• Grant date: Jul 22, 2014
• Expiry date: Jul 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.