Method for manufacturing a boronic acid ester compound
US8785651B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 24, 2009 |
| Grant date | Jul 22, 2014 |
| Priority date | — |
| Expiry date | Jan 9, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.