Compositions and methods for optimizing cleavage of RNA by RNase H
US8790919B2 · kind B2 · utility
4Cited by
12References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2005 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | Apr 9, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3519
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.