Methods related to the treatment of neurodegenerative and inflammatory conditions

US8796302B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Jau-Shyong Hong · Durham, US
• Liya Qin · Durham, US
• Guorong Li · Lo Wu, CN
• Michelle Block · Holly Springs, US
• Wei Zhang · Jinan, CN
• Po-See Chen · Taipei, TW
• Giia-Shuen Peng · Taipei, TW

Key dates

• Filing date: Dec 13, 2011
• Grant date: Aug 5, 2014
• Expiry date: Dec 19, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.