Tetrahydropyran nucleic acid analogs

US8796437B2 · kind B2 · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Eric E. Swayze · Carlsbad, US
• Andrew M. Siwkowski · Carlsbad, US
• Balkrishen Bhat · Carlsbad, US
• Thazha P. Prakash · Carlsbad, US
• Charles Allerson · Carlsbad, US
• Punit P. Seth · Carlsbad, US

Key dates

• Filing date: Apr 17, 2013
• Grant date: Aug 5, 2014
• Expiry date: Apr 17, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.