Patent · US Active

Process for the preparation of proline derivatives

US8796471B2 · kind B2 · utility

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0References

26Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Bjoern Bartels · Schopfheim, DE
Fritz Bliss · Hartheim, DE
Philipp Cueni · Basel, CH
Christophe Pfleger · Mulhouse, FR
Ulrich Zutter · Basel, CH

Key dates

Filing date	Nov 8, 2012
Grant date	Aug 5, 2014
Priority date	—
Expiry date	Nov 8, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D207/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates in part to a process for the preparation of a proline derivative of formula Iwherein, The proline derivatives of the formula I are preferential inhibitors of the cysteine protease Cathepsin S and are therefore useful to treat metabolic diseases like diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease and diabetic nephropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.