HER2/neu-specific antibodies and methods of using same
US8802093B2 · kind B2 · utility
18Cited by
60References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 25, 2009 |
| Grant date | Aug 12, 2014 |
| Priority date | — |
| Expiry date | Dec 27, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.