Patent · US Active

Optimized Fc variants

US8802823B2 · kind B2 · utility

17Cited by

49References

18Claims

0Family size

Assignee

Xencor, Inc. · US

Inventors

Gregory Alan Lazar · Los Angeles, US
Wei Dang · Pasadena, US
John Desjarlais · Pasadena, US
Sher Bahadur Karki · Pasadena, US
Omid Vafa · Monrovia, US
Robert Hayes · Paoli, US
Jost Vielmetter · Altadena, US

Key dates

Filing date	Nov 12, 2013
Grant date	Aug 12, 2014
Priority date	—
Expiry date	Nov 12, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.