Compositions and methods for inhibiting expression of the PCSK9 gene
US8809292B2 · kind B2 · utility
5Cited by
6References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 15, 2012 |
| Grant date | Aug 19, 2014 |
| Priority date | — |
| Expiry date | Jul 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3515
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.