Unnatural reactive amino acid genetic code additions
US8815542B2 · kind B2 · utility
0Cited by
8References
11Claims
0Family size
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Key dates
| Filing date | Mar 6, 2013 |
| Grant date | Aug 26, 2014 |
| Priority date | — |
| Expiry date | Mar 6, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.