Mediators of hedgehog signaling pathways, compositions and uses related hereto
US8815895B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Mar 16, 2012 |
| Grant date | Aug 26, 2014 |
| Priority date | — |
| Expiry date | Aug 4, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.