Multi-domain amphipathic helical peptides and methods of their use

US8835378B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Alan T. Remaley · Bethesda, US
• Stephen J. Demosky · Gaithersburg, US
• John A. Stonik · Gaithersburg, US
• Marcelo Amar · Gaithersburg, US
• Edward B. Neufeld · Washington, US
• H. Bryan Brewer · Potomac, US
• Fairwell Thomas · Rockville, US

Key dates

• Filing date: Feb 28, 2012
• Grant date: Sep 16, 2014
• Expiry date: Jul 11, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.