Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor

US8841287B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Hui Cai · San Diego, US
• Frank Chavez · San Diego, US
• Paul J. Dunford · Solana Beach, US
• Andrew J. Greenspan · San Diego, US
• Steven P. Meduna · San Diego, US
• Jorge A. Quiroz · Princeton, US
• Brad M. Savall · San Diego, US
• Kevin L. Tays · Irvine, US
• Robin Thurmond · San Diego, US
• Jianmei Wei · Town of East Hartford, US
• Ronald L. Wolin · San Diego, US
• Xiaohu Zhang · Suzhou, CN

Key dates

• Filing date: Jun 11, 2009
• Grant date: Sep 23, 2014
• Expiry date: Feb 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.