3-arylamino pyridine derivatives

US8841459B2 · kind B2 · utility

Assignee

• MERCK SERONO SA · CH

Inventors

• Holger Deppe · Heidelberg, DE
• Matthias Schwarz · Gland, CH
• Ulrich Abel · Schifferstadt, DE
• Achim Feurer · Wilhelmsfeld, DE
• Ulrich Grädler · Heidelberg, DE
• Kerstin Otte · Heidelberg, DE
• Renate Sekul · Ladenburg, DE
• Meinolf Thiemann · Schriesheim, DE
• Andreas Goutopoulos · Boston, US
• Xuliang Jiang · Braintree, US

Key dates

• Filing date: Jul 11, 2013
• Grant date: Sep 23, 2014
• Expiry date: Jul 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel, substituted 3-arylamino pyridine compoundspharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.