Thiopyrimidine-based compounds and uses thereof
US8846704B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Jan 31, 2008 |
| Grant date | Sep 30, 2014 |
| Priority date | — |
| Expiry date | Sep 10, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/506
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.