Computational method and apparatus for predicting polypeptide aggregation or solubility
US8849578B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Apr 2, 2008 |
| Grant date | Sep 30, 2014 |
| Priority date | — |
| Expiry date | Apr 30, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/50
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (ΔHydr) between the reference polypeptide and a modified polypeptide, calculating the difference in β-sheet propensity (ΔΔGcoil-α+ΔΔGβ-coil) between the reference polypeptide and modified polypeptide, calculating the difference in charge (Δ Charge) between the reference polypeptide and modified polypeptide, and calculating: [x* ΔHydr]+[y*(ΔΔGcoil-α+ΔΔGβ-coil)]−[z*Δ Charge], wherein x, y and z are scaling factors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.