Human monoclonal antibodies against Hendra and Nipah viruses

US8858938B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• The Henry M. Jackson Foundation of the Advancement of Military Medicine, Inc. · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Zhongyu Zhu · Frederick, US
• Christopher C. Broder · Silver Spring, US

Key dates

• Filing date: Sep 13, 2013
• Grant date: Oct 14, 2014
• Expiry date: Sep 13, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.