Substituted nucleotide analogs

US8871737B2 · kind B2 · utility

Assignee

• ALIOS BIOPHARMA, INC. · US

Inventors

• David Bernard Smith · San Mateo, US
• Jerome Deval · Pacifica, US
• Natalia Dyatkina · Mountain View, US
• Leonid Beigelman · San Mateo, US
• Guangyi Wang · Carlsbad, US

Key dates

• Filing date: Sep 19, 2011
• Grant date: Oct 28, 2014
• Expiry date: Jul 22, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.