Method of preventing or treating viral infection

US8871789B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Thomas Kristie · Silver Spring, US
• Yu-Hsin Liang · Taoyuan, TW
• Jodi Vogel · Bethesda, US
• David J. Maloney · Point of Rocks, US
• Ganesha Rai Bantukallu · Falls Church, US
• Anton Simeonov · Rockville, US
• Ajit Jadhav · Chantilly, US

Key dates

• Filing date: Jan 22, 2013
• Grant date: Oct 28, 2014
• Expiry date: Jan 22, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I):wherein R1, R2, R3, R4, and R5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.