Patent · US Active

Modification of CXCR4 using engineered zinc finger proteins

US8871905B2 · kind B2 · utility

7Cited by

21References

19Claims

0Family size

Assignee

Sangamo Biosciences, Inc. · US

Inventors

Michael C. Holmes · Richmond, US
Jeffrey C. Miller · Pleasanton, US
Jianbin Wang · Richmond, US

Key dates

Filing date	Mar 18, 2010
Grant date	Oct 28, 2014
Priority date	—
Expiry date	Jan 7, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/81
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.