Heteroaryl-substituted urea modulators of fatty acid amide hydrolase

US8877769B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• J. Guy Breitenbucher · Escondido, US
• John M. Keith · San Diego, US
• Mark S. Tichenor · San Diego, US
• Alison L. Chambers · San Diego, US
• William M. Jones · San Diego, US
• Natalie A. Hawryluk · San Diego, US
• Amy K. Timmons · Renton, US
• Jeffrey E. Merit · Stanford, US
• Mark J. Sierestad · San Diego, US

Key dates

• Filing date: May 3, 2013
• Grant date: Nov 4, 2014
• Expiry date: May 3, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).