Patent · US Active

Glycoconjugates of RNA interference agents

US8877917B2 · kind B2 · utility

10Cited by

2References

15Claims

0Family size

Assignee

Alnylam Pharmaceuticals, Inc. · US

Inventors

Andrea Forst · Bayreuth, DE
Philipp Hadwiger · Kulmbach, DE
Hans-Peter Vornlocher · Bayreuth, DE

Key dates

Filing date	Apr 23, 2008
Grant date	Nov 4, 2014
Priority date	—
Expiry date	Jul 18, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.