Synthetic antigenic peptides and lipopeptides derived from Mycobacterium avium subsp. paratuberculosis

US8883173B2 · kind B2 · utility

Assignees

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• INSTITUT NATIONAL DE LA RECHERCHE AGRONOMQIUE · FR
• INSTITUT PASTEUR · FR
• Jean-Marc Reyrat · FR

Inventors

• Jean-Marc Reyrat · Vanves, FR
• Sylvie Bay · Paris, FR
• Franck Biet · Saint-Cyr-sur-Loire, FR

Key dates

• Filing date: Oct 24, 2008
• Grant date: Nov 11, 2014
• Expiry date: May 14, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/35
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The current invention relates to the diagnosis and treatment of diseases resulting from infections by Mycobacterium avium subsp. paratuberculosis. In particular the invention relates to the use of an antigen selected among (a) a synthetic peptide 5P having the following formula: DPhe-NMeVal-Ile-Phe-Ala-OMe (SEQ ID NO: 1); (b) a lipopeptide L5P consisting of the synthetic peptide a) wherein the N-terminal phenylalanine residue is N-acylated with an eicosanoic acid acyl chain; (c) a variant of peptide a) or lipopeptide b) able to react with anti-Mycobacterium paratuberculosis antibodies; for in vitro detection or quantification of specific anti-Mycobacterium paratuberculosis antibodies in a biological sample.