Patent · US Active

Process for preparing modulators of cystic fibrosis transmembrane conductance regulator

US8884018B2 · kind B2 · utility

60Cited by

0References

7Claims

0Family size

Assignee

Vertex Pharmaceuticals Incorporated · US

Inventors

Narendra Bhalchandra Ambhaikar · Hyderabad, IN
Robert Michael Hughes · San Diego, US
Dennis James Hurley · San Marcos, US
Elaine Chungmin Lee · Mundelein, US
Benjamin Littler · Carlsbad, US
Mehdi Michel Djamel Numa · San Diego, US
Stefanie Roeper · Medford, US
Urvi Sheth · San Diego, US

Key dates

Filing date	Mar 7, 2014
Grant date	Nov 11, 2014
Priority date	—
Expiry date	Mar 7, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D215/56
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.