Methods and compositions for modification of the HPRT locus

US8895264B2 · kind B2 · utility

Assignees

• Sangamo Biosciences, Inc. · US
• The Regents of the University of California · US

Inventors

• Gregory J. Cost · Berkeley, US
• Michael C. Holmes · Richmond, US
• Noriyuki Kasahara · Los Angeles, US
• Josee Laganiere · Corona, US
• Jeffrey C. Miller · Pleasanton, US
• David Paschon · Oakland, US
• Edward J. Rebar · Richmond, US
• Fyodor Urnov · Richmond, US
• Lei Zhang · Beijing, CN

Key dates

• Filing date: Oct 25, 2012
• Grant date: Nov 25, 2014
• Expiry date: Oct 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/81
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.