Process for making thienopyrimidine compounds

US8895729B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Srinivasan Babu · San Diego, US
• Zhigang Cheng · Shiqiao, CN
• Francis Gosselin · South San Francisco, US
• Pirmin Hidber · Basel, CH
• Ursula Hoffmann · Muttenz, CH
• Theresa Humphries · San Francisco, US
• Reinhard Reents · Münchenstein, CH
• Qingping Tian · San Diego, US
• Herbert Yajima · San Francisco, US

Key dates

• Filing date: Oct 9, 2013
• Grant date: Nov 25, 2014
• Expiry date: Oct 9, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/185
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure:and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.