4-(4-pyridinyl)-benzamides and their use as rock activity modulators

US8895749B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Helmut Mack · Ludwigshafen, DE
• Nicole Teusch · Uerdingen, DE
• Bernhard Muller
• Wilfried Hornberger · Wiesbaden, DE
• Michael Jarvis · Paducah, US
• Daryl Sauer · Pleasant Prairie, US
• Steven L. Swann, Jr. · San Diego, US
• Dominique Bonafoux · Saint Louis, US
• Ryan G. Keddy · Beach Park, US
• Adrian D. Hobson · Shrewsbury, US
• Anil Vasudevan · Union Grove, US

Key dates

• Filing date: Apr 23, 2013
• Grant date: Nov 25, 2014
• Expiry date: Apr 23, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel 4-(4-pyridyl)-benzamides of the formula (I). The compounds I possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of Rho kinases (ROCKs). R1 and R2 are, independently of each other, hydrogen, hydroxy, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy or C1-C8-haloalkoxy; R3, R4, R5 and R6 are, independently of each other, hydrogen, hydroxy, halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy, C1-C8-haloalkoxy, amino, C1-C8-alkylamino or di-(C1-C8-alkyl)-amino; R7 is hydrogen, C1-C8-alkyl, C1-C8-haloalkyl, aryl or aryl-C1-C8-alkyl; R8 is a group of the formula —X—W, where X is a single bond, C1-C4-alkylene or C1-C4-alkylene-O—, where the alkylene group in the three last-mentioned radicals may be linear or branched and may be partly or fully halogenated and/or may be substituted by a hydroxyl group and/or may be interrupted by an oxygen atom; and W is a cyclic radical selected from phenyl and a 5- or 6-membered saturated, partly unsaturated or aromatic heterocyclic ring which contains as ring members 1, 2 or 3 heteroatoms selected from O, S and N and optionally 1 or 2 ca…