Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent

US8907069B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Ulrich Brinkmann · Weilheim, DE
• Rebecca Croasdale · Antdorf, DE
• Wilma Dormeyer · Munich, DE
• Guy Georges · Habach, DE
• Alexander Haas · Munich, DE
• Eike Hoffmann · Viernheim, DE
• Silke Metz · Annaberg-Buchholz, DE
• Olaf Mundigl · Weilheim, DE
• Werner Scheuer · Penzberg, DE
• Jan Olaf Stracke · Penzberg, DE

Key dates

• Filing date: Jul 5, 2010
• Grant date: Dec 9, 2014
• Expiry date: Jul 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.