High-affinity fully functional soluble single-domain human CD4, antibodies, and related fusion proteins

US8911728B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Weizao Chen · Frederick, US

Key dates

• Filing date: May 20, 2011
• Grant date: Dec 16, 2014
• Expiry date: May 20, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/70
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides engineered antibody domains (eAds), a polypeptide comprising a single domain CD4, as well as a fusion protein comprising the same. Nucleic acids encoding eAd and/or polypeptide or the fusion protein thereof, as well as compositions or cells comprising the eAd, polypeptide, fusion protein, or nucleic acid also are provided.