Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
US8921332B2 · kind B2 · utility
153Cited by
4References
55Claims
0Family size
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Key dates
| Filing date | Mar 12, 2012 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Mar 12, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in an individual in need thereof. Further disclosed are chimeric restriction endonucleases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.