Pyrrolopyridines useful as inhibitors of protein kinase

US8921376B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Mark Ledeboer · Acton, US
• Marion W. Wannamaker · Sharonville, US
• Luc Farmer · Foxborough, US
• Tiansheng Wang · Concord, US
• Albert Pierce · Cambridge, US
• Gabriel Martinez-Botella · Wayland, US
• Randy S. Bethiel · Bedford, US
• Guy Bemis · Arlington, US
• Jian Wang · Newton, US
• Francesco G. Salituro · Marlborough, US
• Michael J. Arnost · North Andover, US
• Jon Come · Cambridge, US
• Jeremy Green · Waltham, US
• Michelle L. Stewart · Cambridge, US
• Craig Marhefka · Belmont, US

Key dates

• Filing date: May 22, 2006
• Grant date: Dec 30, 2014
• Expiry date: Jun 27, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.