Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
US8933085B2 · kind B2 · utility
90Cited by
51References
39Claims
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Key dates
| Filing date | Nov 18, 2011 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Jun 18, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/107
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I:wherein X, Y, Z, L, A, R5, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.