Patent · US Active

Peptides promoting lipid efflux

US8936787B2 · kind B2 · utility

1Cited by

9References

20Claims

0Family size

Assignee

The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

Alan T. Remaley · Bethesda, US
Marcelo Amar · Gaithersburg, US

Key dates

Filing date	Apr 14, 2009
Grant date	Jan 20, 2015
Priority date	—
Expiry date	Jul 22, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are peptides and peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate lipoprotein lipase, and compositions comprising such peptides or combinations thereof. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells and activate lipoprotein lipase within cells are also disclosed herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.