Patent · US Active

Methods and compositions for targeted integration

US8936936B2 · kind B2 · utility

8Cited by

17References

16Claims

0Family size

Assignees

Sangamo Biosciences, Inc. · US
OSPEDALE SAN RAFFAELE S.R.L. · IT

Inventors

Michael C. Holmes · Richmond, US
Shuyuan Yao · San Diego, US
Luigi Naldini · Torino, IT
Angelo Leone Lombardo · Milano, IT

Key dates

Filing date	Oct 23, 2008
Grant date	Jan 20, 2015
Priority date	—
Expiry date	Jan 19, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2840/203
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed herein are methods and compositions for targeted integration of one or more copies of a sequence of interest using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain and integrase defective lentiviral donor constructs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.